1001 - Document - Cover Page link:presentationLink link:definitionLink link:calculationLink 1002 - Statement - Consolidated Balance Sheets link:presentationLink link:definitionLink link:calculationLink 1003 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:definitionLink link:calculationLink 1004 - Statement - Consolidated Statements of Operations link:presentationLink link:definitionLink link:calculationLink 1005 - Statement - Consolidated Statements of Comprehensive Loss link:presentationLink link:definitionLink link:calculationLink 1006 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:definitionLink link:calculationLink 1007 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:definitionLink link:calculationLink 1008 - Disclosure - Organization, Business and Basis of Presentation link:presentationLink link:definitionLink link:calculationLink 1009 - Disclosure - Summary of Significant Accounting Policies link:presentationLink link:definitionLink link:calculationLink 1010 - Disclosure - Liquidity and Uncertainties link:presentationLink link:definitionLink link:calculationLink 1011 - Disclosure - Cash, Cash Equivalents and Marketable Securities link:presentationLink link:definitionLink link:calculationLink 1012 - Disclosure - Accrued Liabilities link:presentationLink link:definitionLink link:calculationLink 1013 - Disclosure - Stockholders' Equity link:presentationLink link:definitionLink link:calculationLink 1014 - Disclosure - Stock-based Compensation link:presentationLink link:definitionLink link:calculationLink 1015 - Disclosure - Leases link:presentationLink link:definitionLink link:calculationLink 1016 - Disclosure - Commitments and Contingencies link:presentationLink link:definitionLink link:calculationLink 1017 - Disclosure - Income Taxes link:presentationLink link:definitionLink link:calculationLink 1018 - Disclosure - Quarterly Financial Data (unaudited) link:presentationLink link:definitionLink link:calculationLink 1019 - Disclosure - Subsequent Event link:presentationLink link:definitionLink link:calculationLink 1020 - Disclosure - Summary of Significant Accounting Policies (Policies) link:presentationLink link:definitionLink link:calculationLink 1021 - Disclosure - Summary of Significant Accounting Policies (Tables) link:presentationLink link:definitionLink link:calculationLink 1022 - Disclosure - Cash, Cash Equivalents and Marketable Securities (Tables) link:presentationLink link:definitionLink link:calculationLink 1023 - Disclosure - Accrued Liabilities (Tables) link:presentationLink link:definitionLink link:calculationLink 1024 - Disclosure - Stock-based Compensation (Tables) link:presentationLink link:definitionLink link:calculationLink 1025 - Disclosure - Leases (Tables) link:presentationLink link:definitionLink link:calculationLink 1026 - Disclosure - Income Taxes (Tables) link:presentationLink link:definitionLink link:calculationLink 1027 - Disclosure - Quarterly Financial Data (unaudited) (Tables) link:presentationLink link:definitionLink link:calculationLink 1028 - Disclosure - Summary of Significant Accounting Policies - Patents (Details) link:presentationLink link:definitionLink link:calculationLink 1029 - Disclosure - Summary of Significant Accounting Policies - Income Taxes (Details) link:presentationLink link:definitionLink link:calculationLink 1030 - Disclosure - Summary of Significant Accounting Policies - Basic and Diluted Loss Per Common Share (Details) link:presentationLink link:definitionLink link:calculationLink 1031 - Disclosure - Liquidity and Uncertainties (Details) link:presentationLink link:definitionLink link:calculationLink 1032 - Disclosure - Cash, Cash Equivalents and Marketable Securities (Details) link:presentationLink link:definitionLink link:calculationLink 1033 - Disclosure - Accrued Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1034 - Disclosure - Stockholders' Equity (Deficit) - Common Stock (Details) link:presentationLink link:definitionLink link:calculationLink 1035 - Disclosure - Stockholders' Equity (Deficit) - Preferred Stock (Details) link:presentationLink link:definitionLink link:calculationLink 1036 - Disclosure - Stockholders' Equity (Deficit) - Registered Offering (Details) link:presentationLink link:definitionLink link:calculationLink 1037 - Disclosure - Stockholders' Equity (Deficit) - At The Market Issuances (Details) link:presentationLink link:definitionLink link:calculationLink 1038 - Disclosure - Stock-based Compensation - Stock Option (Details) link:presentationLink link:definitionLink link:calculationLink 1039 - Disclosure - Stock-based Compensation - Restricted Common Stock (Details) link:presentationLink link:definitionLink link:calculationLink 1040 - Disclosure - Stock-based Compensation - Expense (Details) link:presentationLink link:definitionLink link:calculationLink 1041 - Disclosure - Stock-based Compensation - Unrecognized Expense (Details) link:presentationLink link:definitionLink link:calculationLink 1042 - Disclosure - Leases (Details) link:presentationLink link:definitionLink link:calculationLink 1043 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:definitionLink link:calculationLink 1044 - Disclosure - Income Taxes - Net Operating Loss Carryforwards (Details) link:presentationLink link:definitionLink link:calculationLink 1045 - Disclosure - Income Taxes - Research and Development Carryforward (Details) link:presentationLink link:definitionLink link:calculationLink 1046 - Disclosure - Income Taxes - Valuation Allowance and Uncertain Tax Position (Details) link:presentationLink link:definitionLink link:calculationLink 1047 - Disclosure - Income Taxes - Deferred Tax Assets and Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1048 - Disclosure - Income Taxes - Effective Income Tax Rate (Details) link:presentationLink link:definitionLink link:calculationLink 1049 - Disclosure - Quarterly Financial Data (unaudited) (Details) link:presentationLink link:definitionLink link:calculationLink 1050 - Disclosure - Subsequent Event (Detail) link:presentationLink link:definitionLink link:calculationLink