| UNITED STATES |
| SECURITIES AND EXCHANGE COMMISSION |
| Washington, D.C. 20549 |
SCHEDULE 13G
 
Under the Securities Exchange Act of 1934
(Amendment No.     )*
 
SYNTA PHARMACEUTICALS CORP.
(Name of Issuer)
Common Stock, par value $ 0.0001 per share
(Title of Class of Securities)
87162T 20 6
(CUSIP Number)
December 31, 2007
(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
o | Rule 13d-1(b)
o | Rule 13d-1(c)
x | Rule 13d-1(d)
 
*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
 
The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 
 
CUSIP No. 87162T 20 6 |

1.

Names of Reporting Persons
Lan Bo Chen

| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) |
| | (a) | o |
| | (b) | o |
| 3. | SEC Use Only |

4.

Citizenship or Place of Organization
United States

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
777,535

6.

Shared Voting Power
2,662,417

7.

Sole Dispositive Power
777,535

8.

Shared Dispositive Power
2,662,417

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
3,439,952

| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o | | | | | | | | | | | | | | | | | |

11.

Percent of Class Represented by Amount in Row (9)
10.1%

12.

Type of Reporting Person (See Instructions)
IN

 
2

 
CUSIP No. 87162T 20 6 |

1.

Names of Reporting Persons
Lin-Huey Chen

| 2. | Check the Appropriate Box if a Member of a Group (See Instructions) |
| | (a) | o |
| | (b) | o |
| 3. | SEC Use Only |

4.

Citizenship or Place of Organization
United States

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5.

Sole Voting Power
2,004,016

6.

Shared Voting Power
1,435,936

7.

Sole Dispositive Power
2,004,016

8.

Shared Dispositive Power
1,435,936

9.

Aggregate Amount Beneficially Owned by Each Reporting Person
3,439,952

| 10. | Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) o | | | | | | | | | | | | | | | | | |

11.

Percent of Class Represented by Amount in Row (9)
10.1%

12.

Type of Reporting Person (See Instructions)
IN

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Item 1.

(a)

Name of Issuer
Synta Pharmaceuticals Corp.

(b)

Address of Issuer’s Principal Executive Offices
45 Hartwell Avenue
Lexington, MA 02421

Item 2.

(a)

Name of Person Filing
(i)            Lan Bo Chen
 
(ii)           Lin-Huey Chen

(b)

Address of Principal Business Office or, if none, Residence
(i)            184 East Emerson Road
                Lexington, MA 02420
 
(ii)           184 East Emerson Road
                Lexington, MA 02420

(c)

Citizenship
(i)            United States
 
(ii)           United States

(d)

Title of Class of Securities
Common stock, par value $ 0.0001 per share

(e)

CUSIP Number
87162T 20 6

Item 3. | If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
| (a) | o | Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
| (b) | o | Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
| (c) | o | Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
| (d) | o | Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
| (e) | o | An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
| (f) | o | An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
| (g) | o | A parent holding company or control person in accordance with §240.13d-1(b)(1)(ii)(G);
| (h) | o | A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
| (i) | o | A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
| (j) | o | Group, in accordance with §240.13d-1(b)(1)(ii)(J).

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Item 4. | Ownership
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
| | (i)            Lan Bo Chen

(a)

Amount beneficially owned:   
3,439,952 shares. Consists of 777,535 shares of common stock owned of record by Dr. Lan Bo Chen; 142,223 shares of common stock owned of record by LAJ Holdings LLC, the co-managers of which are Dr. Chen and his spouse, Lin-Huey Chen; 2,004,016 shares of common stock owned of record by the Wisteria Trust, the trustee of which is Dr. Chen’s spouse; 243,481 shares of common stock owned of record by the Ann Chen Trust, a co-trustee of which is Dr. Chen’s spouse; 243,481 shares of common stock owned of record by the Jane Chen Trust, a co-trustee of which is Dr. Chen’s spouse; 12,946 shares of common stock owned of record by the Chen Grandchildren’s Trust, a co-trustee of which is Dr. Chen’s spouse; 10,210 shares of common stock owned of record by the Alexander Chen Wu 2002 Irrevocable Trust, a co-trustee of which is Dr. Chen’s spouse; and 6,060 shares of common stock owned of record by the Allison Chen Wu 2004 Irrevocable Trust, a co-trustee of which is Dr. Chen’s spouse.

(b)

Percent of class:   
10.1%

| (c) | Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote   
777,535

(ii)

Shared power to vote or to direct the vote    
2,662,417

(iii)

Sole power to dispose or to direct the disposition of   
777,535

(iv)

Shared power to dispose or to direct the disposition of   
2,662,417

| | (ii)           Lin-Huey Chen

(a)

Amount beneficially owned:   
3,439,952 shares. Consists of 777,535 shares of common stock owned of record by Mrs. Chen’s spouse, Dr. Lan Bo Chen; 142,223 shares of common stock owned of record by LAJ Holdings LLC, of which Mrs. Chen and her spouse are co-managers; 2,004,016 shares of common stock owned of record by the Wisteria Trust, of which Mrs. Chen is the trustee; 243,481 shares of common stock owned of record by the Ann Chen Trust, of which Mrs. Chen is a co-trustee; 243,481 shares of common stock owned of record by the Jane Chen Trust, of which Mrs. Chen is a co-trustee; 12,946 shares of common stock owned of record by the Chen Grandchildren’s Trust, of which Mrs. Chen is a co-trustee; 10,210 shares of common stock owned of record by the Alexander Chen Wu 2002 Irrevocable Trust, of which Mrs. Chen is a co-trustee; and 6,060 shares of common stock owned of record by the Allison Chen Wu 2004 Irrevocable Trust, of which Mrs. Chen is a co-trustee.

(b)

Percent of class:   
10.1%

| (c) | Number of shares as to which the person has:

(i)

Sole power to vote or to direct the vote   
2,004,016

(ii)

Shared power to vote or to direct the vote    
1,435,936

(iii)

Sole power to dispose or to direct the disposition of   
2,004,016

(iv)

Shared power to dispose or to direct the disposition of   
1,435,936

Item 5. | Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following   o .
Not Applicable
Item 6. | Ownership of More than Five Percent on Behalf of Another Person
Not Applicable
Item 7. | Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person
Not Applicable
Item 8. | Identification and Classification of Members of the Group
Not Applicable
Item 9. | Notice of Dissolution of Group
Not Applicable

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Item 10. | Certification
Not Applicable
 
Signature
 
After reasonable inquiry and to the best of my knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct.
 
Date:  February 14, 2008 | /s/ Lan Bo Chen
| Lan Bo Chen
Date:  February 14, 2008 | /s/ Lin-Huey Chen
| Lin-Huey Chen

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EXHIBIT A
 
JOINT ACQUISITION STATEMENT
PURSUANT TO RULE 13d-1(k)(1)
 
The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint acquisition statements.  The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained therein, but shall not be responsible for the completeness and accuracy of the information concerning the other, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate.
 
Date:  February 14, 2008 | /s/ Lan Bo Chen
| Lan Bo Chen
Date:  February 14, 2008 | /s/ Lin-Huey Chen
| Lin-Huey Chen

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